Hydrochloric Acid → 5-{4-Oxospiro[chroman-2,4'-piperidin]-6-yl}nicotinamide dihydrochloride

HRID 38475

反応式

C(OC([N:8]1[CH2:13][CH2:12][C:11]2([CH2:22][C:21](=[O:23])[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([C:24]4[CH:25]=[N:26][CH:27]=[C:28]([CH:32]=4)[C:29]([NH2:31])=[O:30])[CH:19]=3)[O:14]2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:33]>O1CCOCC1>[ClH:33].[ClH:33].[O:23]=[C:21]1[C:20]2[C:15](=[CH:16][CH:17]=[C:18]([C:24]3[CH:25]=[N:26][CH:27]=[C:28]([CH:32]=3)[C:29]([NH2:31])=[O:30])[CH:19]=2)[O:14][C:11]2([CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[CH2:22]1

参加物

実験手順

5-{1′-tert-butoxycarbonyl-4-oxospiro[chroman-2,4′-piperidin]-6-yl}nicotinamide (1.30 g) was suspended in dioxane (10 ml) and 4N HCl in dioxane (20 ml) was added thereto, and stirred at room temperature for 18 h. The resulted precipitate was filtered, washed with dioxane and Et2O to obtain the intended compound as a colorless solid.

後処理

filtrationThe resulted precipitate was filtered
washwashed with dioxane and Et2O

出典と根拠

ORDレコード: ord-1fa9396ccade412b86164f9adbce59fa
出典データセット: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08524730B2

反応式

参加物

反応物 2

生成物 1

試薬・触媒・溶媒 1

実験手順

後処理

出典と根拠

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