Methanol → 3,4-Dihydro-6-hydroxy-4-oxoquinazoline

HRID 384758

反応式

HRID 384758 の反応式
[OH:1][C:2]1[CH:10]=[C:6]([C:7](O)=[O:8])[C:5]([NH2:11])=[CH:4][CH:3]=1.C([O-])([O-])OC.C([O-])(=O)C.[NH4+:21].[CH3:22]O>O>[OH:1][C:2]1[CH:10]=[C:6]2[C:5](=[CH:4][CH:3]=1)[N:11]=[CH:22][NH:21][C:7]2=[O:8]

参加物

6

反応物 4

HCID 887MethanolHCID 1645925-Hydroxyanthranilic acidHCID 517165Ammonium AcetateHCID 53629101Methylorthoformate

生成物 1

HCID 1354895773,4-Dihydro-6-hydroxy-4-oxoquinazoline収率 74%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

In a 10-mL volume stainless steel pressure-resistant vessel were placed 1.00 g (6.6 mmol) of 5-hydroxyanthranilic acid, 2.80 g (26.4 mmol) of methyl orthoformate, 2.00 g (26.4 mmol) of ammonium acetate, and 4.0 mL of methanol. The reaction was carried out at 120° C. for 3 hours. After the reaction was complete, the reaction mixture was cooled to room temperature, and 40 mL of water was added to the reaction mixture. The resulting aqueous mixture was stirred for 15 minutes and filtered to give 0.78 g (isolated yield: 74%) of 6-hydroxyquinazolin-4-one as a pale gray crystalline product.

後処理

  1. customIn a 10-mL volume stainless steel pressure-resistant vessel were placed
  2. filtrationfiltered

出典と根拠

ORDレコード
ord-4d4f9badbf8448768272e896d70f5120
出典データセット
uspto-grants-2013_02
特許番号
US08367824B2

関連ノート

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