Hydrochloric Acid → 6-(4-Oxospiro[chroman-2,4'-piperidin]-6-yl)nicotinamide dihydrochloride

HRID 38479

反応式

HRID 38479 の反応式
[C:1]([C:4]1[CH:5]=[CH:6][C:7]([C:10]2[CH:11]=[C:12]3[C:29](=[CH:30][CH:31]=2)[O:28][C:15]2([CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]2)[CH2:14][C:13]3=[O:32])=[N:8][CH:9]=1)(=[O:3])[NH2:2].[ClH:33].CCOCC>O1CCOCC1>[ClH:33].[ClH:33].[O:32]=[C:13]1[C:12]2[C:29](=[CH:30][CH:31]=[C:10]([C:7]3[CH:6]=[CH:5][C:4]([C:1]([NH2:2])=[O:3])=[CH:9][N:8]=3)[CH:11]=2)[O:28][C:15]2([CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[CH2:14]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 58208682tert-Butyl 6-(5-carbamoylpyridin-2-yl)-4-oxospiro[chroman-2,4'-piperidine]-1'-carboxylate

生成物 1

HCID 667818846-(4-Oxospiro[chroman-2,4'-piperidin]-6-yl)nicotinamide dihydrochloride

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

To a suspension of tert-butyl 6-(5-carbamoylpyridin-2-yl)-4-oxospiro[chroman-2,4′-piperidine]-1′-carboxylate in dioxane (125 ml) was added 4N HCl in dioxane (125 ml) and the mixture was stirred for 18 h. After Et2O was added to the mixture, the resulted precipitate was collected by aeration, washed with Et2O to give intended compound as a colorless solid.

後処理

  1. customthe resulted precipitate was collected by aeration
  2. washwashed with Et2O
  3. customto give

出典と根拠

ORDレコード
ord-6add63eca05c4a7ea8bd746aa231ffd3
出典データセット
uspto-grants-2013_09
特許番号
US08524730B2

関連ノート

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