Potassium Carbonate → 1-Bromo-2-fluoro-4-(2,2,3,3,3-pentafluoro-propoxy)-benzene

HRID 384892ノート

反応式

HRID 384892 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[F:9].O([CH2:18][C:19]([F:25])([F:24])[C:20]([F:23])([F:22])[F:21])S(C(F)(F)F)(=O)=O.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:18][C:19]([F:25])([F:24])[C:20]([F:23])([F:22])[F:21])=[CH:4][C:3]=1[F:9]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 27760192,2,3,3,3-Pentafluoropropyl trifluoromethanesulfonateHCID 27791534-Bromo-3-fluorophenol

生成物 1

HCID 874432981-Bromo-2-fluoro-4-(2,2,3,3,3-pentafluoro-propoxy)-benzene

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

The title compound was prepared from 4-bromo-3-fluorophenol and 2,2,3,3,3,-pentafluoropropyl triflate with potassium carbonate in acetone at ambient temperature for 18 hours. Kugelrohr distillation provided a colorless oil, b.p. 105-110° C./12 mbar.

後処理

  1. distillationKugelrohr distillation
  2. customprovided a colorless oil, b.p. 105-110° C./12 mbar

出典と根拠

ORDレコード
ord-7ef815b8595f4da1b115d094560517b9
出典データセット
uspto-grants-2013_02
特許番号
US08367838B2

反応ノート

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