(5-Fluoropyridin-3-yl)boronic acid → Rac-[1-(3,4-dichloro-phenyl)-2-[4-(5-fluoro-pyridin-3-yl)-3-methoxy-phenyl]-2-oxo-ethyl]-carbamic acid tert-butyl ester

HRID 384898ノート

反応式

HRID 384898 の反応式
[C:1]([O:5][C:6](=[O:28])[NH:7][CH:8]([C:20]1[CH:25]=[CH:24][C:23]([Cl:26])=[C:22]([Cl:27])[CH:21]=1)[C:9]([C:11]1[CH:16]=[CH:15][C:14](Br)=[C:13]([O:18][CH3:19])[CH:12]=1)=[O:10])([CH3:4])([CH3:3])[CH3:2].[F:29][C:30]1[CH:31]=[C:32](B(O)O)[CH:33]=[N:34][CH:35]=1>>[C:1]([O:5][C:6](=[O:28])[NH:7][CH:8]([C:20]1[CH:25]=[CH:24][C:23]([Cl:26])=[C:22]([Cl:27])[CH:21]=1)[C:9]([C:11]1[CH:16]=[CH:15][C:14]([C:32]2[CH:33]=[N:34][CH:35]=[C:30]([F:29])[CH:31]=2)=[C:13]([O:18][CH3:19])[CH:12]=1)=[O:10])([CH3:4])([CH3:3])[CH3:2]

参加物

3

反応物 2

HCID 44717403(5-Fluoropyridin-3-yl)boronic acidHCID 68409180Rac-[2-(4-bromo-3-methoxy-phenyl)-1-(3,4-dichloro-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

生成物 1

HCID 68410003Rac-[1-(3,4-dichloro-phenyl)-2-[4-(5-fluoro-pyridin-3-yl)-3-methoxy-phenyl]-2-oxo-ethyl]-carbamic acid tert-butyl ester

実験手順

The title compound was prepared from rac-[2-(4-bromo-3-methoxy-phenyl)-1-(3,4-dichloro-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester and 5-fluoropyridine-3-boronic acid in analogy to Example 1b): MS (ISN): 503.0 (M−H)− and 429.01 ((M-tBuOH)−H)−.

出典と根拠

ORDレコード
ord-0701e393674b4e649b2df3043991854b
出典データセット
uspto-grants-2013_02
特許番号
US08367838B2

反応ノート

読み込み中…