(4-Bromophenoxy)(tert-butyl)dimethylsilane → Rac-[2-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-1-(4-chloro-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

HRID 384904

反応式

HRID 384904 の反応式
[C:1]([O:5][C:6](=[O:22])[NH:7][CH:8]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=1)[C:9](=[O:14])N(OC)C)([CH3:4])([CH3:3])[CH3:2].Br[C:24]1[CH:37]=[CH:36][C:27]([O:28][Si:29]([C:32]([CH3:35])([CH3:34])[CH3:33])([CH3:31])[CH3:30])=[CH:26][CH:25]=1>>[C:1]([O:5][C:6](=[O:22])[NH:7][CH:8]([C:15]1[CH:16]=[CH:17][C:18]([Cl:21])=[CH:19][CH:20]=1)[C:9]([C:24]1[CH:37]=[CH:36][C:27]([O:28][Si:29]([C:32]([CH3:35])([CH3:34])[CH3:33])([CH3:30])[CH3:31])=[CH:26][CH:25]=1)=[O:14])([CH3:2])([CH3:3])[CH3:4]

参加物

3

反応物 2

HCID 4227167(4-Bromophenoxy)(tert-butyl)dimethylsilaneHCID 71663866HCID 71663866、化合物2 回

生成物 1

HCID 68412036Rac-[2-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-1-(4-chloro-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

実験手順

The title compound was prepared from rac-[(4-chloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester (Intermediate 8) and (4-bromo-phenoxy)-tert-butyl-dimethyl-silane in analogy to Example 1a): MS (ISP): 476.0 (M+H)+.

出典と根拠

ORDレコード
ord-a2b48290844b417899969e918ab83629
出典データセット
uspto-grants-2013_02
特許番号
US08367838B2

関連ノート

読み込み中…