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HRID 384909作成日：2026年10月26日

3-(Methylsulfonyl)phenylboronic acid → Rac-[1-(3,4-dichloro-phenyl)-2-[5-(3-methanesulfonyl-phenyl)-pyridin-2-yl]-2-oxo-ethyl]-carbamic acid tert-butyl ester

https://huagongshe.com/reaction/384909

反応式

関与物質

役割名称HCID仕込み量
反応物3-(Methylsulfonyl)phenylboronic acidHCID 2773542—
反応物Rac-[2-(5-bromo-pyridin-2-yl)-1-(3,4-dichloro-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl esterHCID 68409891—
生成物Rac-[1-(3,4-dichloro-phenyl)-2-[5-(3-methanesulfonyl-phenyl)-pyridin-2-yl]-2-oxo-ethyl]-carbamic acid tert-butyl esterHCID 68408989—

反応手順

The title compound was prepared from rac-[2-(5-bromo-pyridin-2-yl)-1-(3,4-dichloro-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester and 3-methylsulfonylphenylboronic acid in analogy to Example 1b): MS (ISP): 535.1 and 536.1 (M+H)+, 479.1 and 481.0 ((M-isobutene)+H)+ (100%).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08367838B2
出典データセットuspto-grants-2013_02
ORD IDord-b394a735940346538d506c7e245b7f14
出典メモuspto-grants-2013_02