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HRID 384916作成日：2026年10月27日

4-(4-Bromo-2,6-difluoro-phenoxy)-tetrahydro-pyran → Rac-[1-(3,4-dichloro-phenyl)-2-[3,5-difluoro-4-(tetrahydro-pyran-4-yloxy)-phenyl]-2-oxo-ethyl]-carbamic acid tert-butyl ester

https://huagongshe.com/reaction/384916

反応式

関与物質

役割名称HCID仕込み量
反応物4-(4-Bromo-2,6-difluoro-phenoxy)-tetrahydro-pyranHCID 68409276—
反応物Rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl esterHCID 87442373—
生成物Rac-[1-(3,4-dichloro-phenyl)-2-[3,5-difluoro-4-(tetrahydro-pyran-4-yloxy)-phenyl]-2-oxo-ethyl]-carbamic acid tert-butyl esterHCID 68410060—

反応手順

The title compound was prepared from rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester (Intermediate 9) and 4-(4-bromo-2,6-difluoro-phenoxy)-tetrahydro-pyran (Intermediate 18) in analogy to Example 1a): MS (ISP): 516.1 and 518.1 (M+H)+, 416.2 and 418.0 ((M-Boc)+H)+ (100%).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08367838B2
出典データセットuspto-grants-2013_02
ORD IDord-abe192268957436c848b09cf772c0fa4
出典メモuspto-grants-2013_02