3-Bromo-6-isopropoxy-2-methylpyridine → 1-(3,4-Dichloro-phenyl)-2-(6-isopropoxy-2-methyl-pyridin-3-yl)-2-oxo-ethyl-carbamic acid tert-butyl ester
反応式
[C:1]([O:5][C:6](=[O:23])[NH:7][CH:8]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=1)[C:9](=[O:14])N(OC)C)([CH3:4])([CH3:3])[CH3:2].Br[C:25]1[C:26]([CH3:35])=[N:27][C:28]([O:31][CH:32]([CH3:34])[CH3:33])=[CH:29][CH:30]=1>>[C:1]([O:5][C:6](=[O:23])[NH:7][CH:8]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=1)[C:9]([C:25]1[C:26]([CH3:35])=[N:27][C:28]([O:31][CH:32]([CH3:33])[CH3:34])=[CH:29][CH:30]=1)=[O:14])([CH3:2])([CH3:3])[CH3:4]参加物
3
実験手順
The title compound was prepared from rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester (Intermediate 9) and 3-bromo-6-isopropoxy-2-methyl-pyridine (Intermediate 25) in analogy to Example 1a): MS (ISP): 453.2 and 455.2 (M+H)+.