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4-(4-Bromo-3-fluoro-phenoxy)-tetrahydro-pyran → Rac-[1-(3,4-dichloro-phenyl)-2-[2-fluoro-4-(tetrahydro-pyran-4-yloxy)-phenyl]-2-oxo-ethyl]-carbamic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(4-Bromo-3-fluoro-phenoxy)-tetrahydro-pyran | HCID 65202995 | — |
| 反応物 | Rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester | HCID 87442373 | — |
| 生成物 | Rac-[1-(3,4-dichloro-phenyl)-2-[2-fluoro-4-(tetrahydro-pyran-4-yloxy)-phenyl]-2-oxo-ethyl]-carbamic acid tert-butyl ester | HCID 68409793 | — |
反応手順
The title compound was prepared from rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester (Intermediate 9) and 4-(4-bromo-3-fluoro-phenoxy)-tetrahydro-pyran (Intermediate 31) in analogy to Example 1a): MS (ISP): 498.1 and 500.2 (M+H)+, 442.2 and 444.0 ((M-isobutene)+H)+ (100%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08367838B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-757f02853d85431fa96f247cc12d7717 |
| 出典メモ | uspto-grants-2013_02 |