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(4-Bromophenoxy)(tert-butyl)dimethylsilane → Rac-[2[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-1-(3,4-dichloro-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (4-Bromophenoxy)(tert-butyl)dimethylsilane | HCID 4227167 | — |
| 反応物 | Rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester | HCID 87442373 | — |
| 生成物 | Rac-[2[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-1-(3,4-dichloro-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester | HCID 68408872 | — |
反応手順
The title compound was prepared from rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester (Intermediate 9) and (4-bromo-phenoxy)-tert-butyl-dimethyl-silane in analogy to Example 1a): MS (ISP): 510.3 and 512.2 (M+H)+, 410.1 and 412.1 ((M-Boc)+H)+ (100%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08367838B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-5273946c20e14dd9bfe93e86099fa1f3 |
| 出典メモ | uspto-grants-2013_02 |