Water → 1-(Methoxymethoxy)-2-(trifluoromethoxy)benzene

HRID 385139ノート

反応式

HRID 385139 の反応式
[F:1][C:2]([F:12])([F:11])[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[OH:10].C(=O)([O-])[O-].[K+].[K+].[CH3:19][O:20][CH2:21]Cl.O>CN(C)C=O>[CH3:19][O:20][CH2:21][O:10][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[O:3][C:2]([F:11])([F:12])[F:1]

参加物

6

反応物 4

HCID 962WaterHCID 7864Chloromethyl Methyl EtherHCID 11430Potassium CarbonateHCID 27772992-(Trifluoromethoxy)phenol

生成物 1

HCID 121796491-(Methoxymethoxy)-2-(trifluoromethoxy)benzene

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

2-trifluoromethoxyphenol (10.00 g) was dissolved in N,N-dimethylformamide (50 mL), and potassium carbonate (15.52 g) and chloromethyl methyl ether (4.70 mL) were added to the solution, and then the mixture was stirred at room temperature for 1 hour. Water was added to the reaction solution and then the mixture was extracted with n-hexane. The organic layer was washed with saturated brine, and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain the title compound (12.21 g) as a colorless oily substance.

後処理

  1. extractionthe mixture was extracted with n-hexane
  2. washThe organic layer was washed with saturated brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. distillationThe solvent was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-2a5352a87090459c9c3b9860d9787a1a
出典データセット
uspto-grants-2013_02
特許番号
US08367843B2

反応ノート

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