Ethyl orthoformate → 5-Bromo-1-diethoxymethyl-2-methoxy-3-trifluoromethoxybenzene

HRID 385142ノート

反応式

HRID 385142 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([O:12][C:13]([F:16])([F:15])[F:14])[C:5]([O:10][CH3:11])=[C:6]([CH:9]=1)C=O.[CH:17]([O:24][CH2:25][CH3:26])([O:21][CH2:22][CH3:23])OCC>CCCCCC>[Br:1][C:2]1[CH:3]=[C:4]([O:12][C:13]([F:14])([F:15])[F:16])[C:5]([O:10][CH3:11])=[C:6]([CH:17]([O:21][CH2:22][CH3:23])[O:24][CH2:25][CH3:26])[CH:9]=1

参加物

4

反応物 2

HCID 31214Ethyl orthoformateHCID 866681815-Bromo-2-methoxy-3-(trifluoromethoxy)benzaldehyde

生成物 1

HCID 681086775-Bromo-1-diethoxymethyl-2-methoxy-3-trifluoromethoxybenzene

試薬・触媒・溶媒 1

HCID 8058Hexane溶媒

実験手順

5-bromo-2-methoxy-3-trifluoromethoxybenzaldehyde (5.22 g) was dissolved in n-hexane (15 mL) and triethyl orthoformate (4.4 mL), and Amberlyst-15 (522 mg) was added to the solution, and then the mixture was refluxed for 3 hours. The reaction solution was filtered, and then the solvent was distilled off under reduced pressure to obtain the title compound (6.19 g) as a brown oily substance.

後処理

  1. temperaturethe mixture was refluxed for 3 hours
  2. filtrationThe reaction solution was filtered
  3. distillationthe solvent was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-a9f2bd6d3f5c4c60a296d297a85a4611
出典データセット
uspto-grants-2013_02
特許番号
US08367843B2

反応ノート

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