Potassium Hydroxide → N-(3,4-Dichlorophenyl)-6,7-dihydro-5H-pyrrolo[3',4':4,5]thieno[2,3-d]pyrimidin-4-amine

HRID 38526

反応式

HRID 38526 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:11]3[C:18]4[CH2:19][N:20](C(OCC)=O)[CH2:21][C:17]=4[S:16][C:12]=3[N:13]=[CH:14][N:15]=2)[CH:5]=[CH:6][C:7]=1[Cl:8].[OH-].[K+]>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:11]3[C:18]4[CH2:19][NH:20][CH2:21][C:17]=4[S:16][C:12]=3[N:13]=[CH:14][N:15]=2)[CH:5]=[CH:6][C:7]=1[Cl:8]

参加物

3

反応物 2

HCID 14797Potassium HydroxideHCID 58116842Ethyl 4-[(3,4-dichlorophenyl)amino]-5,7-dihydro-6H-pyrrolo[3',4':4,5]thieno[2,3-d]pyrimidine-6-carboxylate

生成物 1

HCID 58116802N-(3,4-Dichlorophenyl)-6,7-dihydro-5H-pyrrolo[3',4':4,5]thieno[2,3-d]pyrimidin-4-amine収率 59%

実験手順

In analogy to Example 23A, ethyl 4-[(3,4-dichlorophenyl)amino]-5,7-dihydro-6H-pyrrolo[3′,4′:4,5]thieno[2,3-d]pyrimidine-6-carboxylate from Example 24A (324 mg, 0.79 mmol) was treated with aqueous potassium hydroxide solution to yield 157 mg (59%) of the title compound.

出典と根拠

ORDレコード
ord-e822b1cbddab45f5a8568328a9478d0d
出典データセット
uspto-grants-2013_09
特許番号
US08524722B2

関連ノート

読み込み中…