2,3-Diamino-6-methoxypyridine dihydrochloride → 2-(2-Dimethylamino-4-nitro-phenyl)-5-methoxy-imidazo[4,5-b]pyridine

HRID 3853ノート

反応式

HRID 3853 の反応式
[CH3:1][N:2]([CH3:15])[C:3]1[CH:11]=[C:10]([N+:12]([O-:14])=[O:13])[CH:9]=[CH:8][C:4]=1[C:5](O)=O.Cl.Cl.[NH2:18][C:19]1[C:24]([NH2:25])=[CH:23][CH:22]=[C:21]([O:26][CH3:27])[N:20]=1>P(Cl)(Cl)(Cl)=O>[CH3:1][N:2]([CH3:15])[C:3]1[CH:11]=[C:10]([N+:12]([O-:14])=[O:13])[CH:9]=[CH:8][C:4]=1[C:5]1[NH:25][C:24]2[C:19]([N:18]=1)=[N:20][C:21]([O:26][CH3:27])=[CH:22][CH:23]=2

参加物

4

反応物 2

HCID 30239192,3-Diamino-6-methoxypyridine dihydrochlorideHCID 201382202-(Dimethylamino)-4-nitrobenzoic acid

生成物 1

HCID 135323492-(2-Dimethylamino-4-nitro-phenyl)-5-methoxy-imidazo[4,5-b]pyridine

試薬・触媒・溶媒 1

HCID 24813Phosphorus oxychloride溶媒

実験手順

An amount of 0.45 gm of 2-dimethylamino-4-nitro-benzoic acid is suspended in 15 ml of phosphorus oxychloride, and 0.45 gm of 2,3-diamino-6-methoxy-pyridine dihydrochloride are added. The mixture is refluxed for two hours and after cooling poured onto water. The aqueous solution is made ammoniacal with cooling, and the product precipitated is treated as in Example 4(b).

後処理

  1. temperatureThe mixture is refluxed for two hours
  2. temperatureafter cooling
  3. additionpoured onto water
  4. temperaturewith cooling
  5. customthe product precipitated
  6. additionis treated as in Example 4(b)

出典と根拠

ORDレコード
ord-2a7e3c04034f4962805f2b8605f567fe
出典データセット
uspto-grants-1988_02
特許番号
US04722929

反応ノート

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