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5-nitro-1-(pyridin-2-ylmethyl)-1H-indazole → 1-(Pyridin-2-ylmethyl)-1H-indazol-5-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-nitro-1-(pyridin-2-ylmethyl)-1H-indazole | HCID 22496149 | — |
| 触媒 | Adams' catalyst | HCID 345198 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 1-(Pyridin-2-ylmethyl)-1H-indazol-5-amine | HCID 21952366 | — |
反応手順
A solution of the compound from Example 60A (6.73 g, 26.5 mmol) in ethanol (70 mL) was stirred with platinum dioxide (200 mg) under a hydrogen atmosphere at normal pressure for 3 h. The catalyst was removed by suction filtration, and the solvent was removed in vacuo. The residue was triturated with tert-butyl methyl ether, and the product was collected by suction filtration to yield 5.1 g (86%) as white crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08524722B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-90eb0bc831d741f39e86405fc8981e47 |
| 出典メモ | uspto-grants-2013_09 |