Ethanol hydrochloride → 1-(2-(4-aminopiperidin-1-yl)ethyl)-7-methoxy-1,5-naphthyridin-2(1H)-one hydrochloride

HRID 385529ノート

反応式

HRID 385529 の反応式
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][C:9](=[O:29])[N:10]2[CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][CH:18]([NH:21]C(=O)OC(C)(C)C)[CH2:17][CH2:16]2)=[N:5][CH:4]=1.[ClH:30].C(O)C>C(O)C>[ClH:30].[NH2:21][CH:18]1[CH2:17][CH2:16][N:15]([CH2:14][CH2:13][N:10]2[C:11]3[C:6](=[N:5][CH:4]=[C:3]([O:2][CH3:1])[CH:12]=3)[CH:7]=[CH:8][C:9]2=[O:29])[CH2:20][CH2:19]1

参加物

4

反応物 2

HCID 21887872Ethanol hydrochlorideHCID 57815396tert-butyl (1-(2-(7-methoxy-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)carbamate

生成物 1

HCID 689270711-(2-(4-aminopiperidin-1-yl)ethyl)-7-methoxy-1,5-naphthyridin-2(1H)-one hydrochloride

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 0.23 g of tert-butyl (1-(2-(7-methoxy-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)carbamate in 5 mL of ethanol, 5 mL of a 6.0 mol/L hydrogen chloride/ethanol solution was added at room temperature and the mixture was stirred for 1 hour. The solvent was distilled off under reduced pressure, diethyl ether was added to the resultant residue, and the solid was filtered off to obtain 0.22 g of 1-(2-(4-aminopiperidin-1-yl)ethyl)-7-methoxy-1,5-naphthyridin-2(1H)-one hydrochloride as a light yellow solid.

後処理

  1. distillationThe solvent was distilled off under reduced pressure, diethyl ether
  2. additionwas added to the resultant residue
  3. filtrationthe solid was filtered off

出典と根拠

ORDレコード
ord-12753648f29b47a3b489040cee6e1d2f
出典データセット
uspto-grants-2013_02
特許番号
US08367831B2

反応ノート

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