Potassium Hydroxide → Tert-butyl (3,4-dichloro-5-hydroxyphenyl)carbamate

HRID 38553ノート

反応式

HRID 38553 の反応式
[C:1]([O:5][C:6](=[O:17])[NH:7][C:8]1[CH:13]=[C:12](Cl)[C:11]([Cl:15])=[C:10]([Cl:16])[CH:9]=1)([CH3:4])([CH3:3])[CH3:2].[OH-:18].[K+]>>[C:1]([O:5][C:6](=[O:17])[NH:7][C:8]1[CH:13]=[C:12]([OH:18])[C:11]([Cl:15])=[C:10]([Cl:16])[CH:9]=1)([CH3:4])([CH3:3])[CH3:2]

参加物

3

反応物 2

HCID 14797Potassium HydroxideHCID 18929852N-(tert-Butoxycarbonyl)-3,4,5-trichloroaniline

生成物 1

HCID 58116863Tert-butyl (3,4-dichloro-5-hydroxyphenyl)carbamate

反応条件

温度
90 °C

実験手順

In analogy to Example 63A, tert-butyl(3,4,5-trichlorophenyl)carbamate from Example 66A (3.98 g, 13.4 mmol) was reacted with potassium hydroxide (1.77 g, 26.8 mmol). The reaction mixture was heated to 80° C. overnight and subsequently to 90° C. for 3 h. The product was isolated by preparative HPLC to yield 760 mg (20%).

後処理

  1. customThe product was isolated by preparative HPLC
  2. customto yield 760 mg (20%)

出典と根拠

ORDレコード
ord-2834e6463a5c4394b92d7a553004b9d3
出典データセット
uspto-grants-2013_09
特許番号
US08524722B2

反応ノート

読み込み中…