化工社化工社 化学情報印刷レポート · 研究参考用
3-Chloro-4-fluoroaniline → N-(3-Chloro-4-fluorophenyl)-6,7,8,9-tetrahydro-5H-pyrimido[5',4':4,5]thieno[2,3-d]azepin-4-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Chloro-4-fluoroaniline | HCID 9708 | — |
| 反応物 | tert-Butyl 4-chloro-5,6,8,9-tetrahydro-7H-pyrimido[5',4':4,5]thieno[2,3-d]azepine-7-carboxylate | HCID 58116942 | — |
| 生成物 | N-(3-Chloro-4-fluorophenyl)-6,7,8,9-tetrahydro-5H-pyrimido[5',4':4,5]thieno[2,3-d]azepin-4-amine | HCID 66850022 | — |
反応手順
The title compound was prepared in analogy to Example 12A from tert-butyl 4-chloro-5,6,8,9-tetrahydro-7H-pyrimido[5′,4′:4,5]thieno[2,3-d]azepine-7-carboxylate from Example 84A (680 mg, 2.00 mmol) and 3-chloro-4-fluoroaniline (306 mg, 2.10 mmol) to yield 419 mg (60%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08524722B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-bebfec6126034f30b4fe6f76eaf11fd8 |
| 出典メモ | uspto-grants-2013_09 |