2-Fluorophenylboronic acid → Benzyl[3-(aminocarbonyl)-5-(2-fluorophenyl)-2-thienyl]carbamate
反応式
[CH2:1]([O:8][C:9](=[O:20])[NH:10][C:11]1[S:12][C:13](I)=[CH:14][C:15]=1[C:16]([NH2:18])=[O:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1B(O)O>>[CH2:1]([O:8][C:9](=[O:20])[NH:10][C:11]1[S:12][C:13]([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=2[F:21])=[CH:14][C:15]=1[C:16]([NH2:18])=[O:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
3
実験手順
The title compound was synthesized from benzyl[3-(aminocarbonyl)-5-iodo-2-thienyl]carbamate (Intermediate 1, Step 2) (300 mg, 0.746 mmol) and 2-fluorophenyl boronic acid (157 mg, 1.12 mmol) as the starting materials as described in Intermediate 1 Step 3.
出典と根拠
- ORDレコード
- ord-5ad4fd2c9e0b4214a66f96e6c58b7cc7
- 出典データセット
- uspto-grants-2013_02
- 特許番号
- US08367706B2
反応ノート
読み込み中…