1-(3-Fluorobenzyl)-1H-indazol-5-amine → tert-Butyl 3-cyano-4-{[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino}-5,8-dihydrothieno[2,3-b:5,4-c']-dipyridine-7(6H)-carboxylate

HRID 38570

反応式

HRID 38570 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][CH:18]=1)[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([NH2:15])=[CH:12][CH:13]=2)[CH:8]=[N:7]1.Cl[C:20]1[C:25]([C:26]#[N:27])=[CH:24][N:23]=[C:22]2[S:28][C:29]3[CH2:30][N:31]([C:35]([O:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:36])[CH2:32][CH2:33][C:34]=3[C:21]=12>>[C:26]([C:25]1[C:20]([NH:15][C:11]2[CH:10]=[C:9]3[C:14](=[CH:13][CH:12]=2)[N:6]([CH2:5][C:4]2[CH:16]=[CH:17][CH:18]=[C:2]([F:1])[CH:3]=2)[N:7]=[CH:8]3)=[C:21]2[C:34]3[CH2:33][CH2:32][N:31]([C:35]([O:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:36])[CH2:30][C:29]=3[S:28][C:22]2=[N:23][CH:24]=1)#[N:27]

参加物

3

反応物 2

HCID 71470731-(3-Fluorobenzyl)-1H-indazol-5-amineHCID 58116935tert-Butyl 4-chloro-3-cyano-5,8-dihydrothieno[2,3-b:5,4-c']dipyridine-7(6H)-carboxylate

生成物 1

HCID 58116903tert-Butyl 3-cyano-4-{[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino}-5,8-dihydrothieno[2,3-b:5,4-c']-dipyridine-7(6H)-carboxylate

実験手順

In analogy to Example 54A, the title compound was synthesized from 1-(3-fluorobenzyl)-1H-indazol-5-amine from Example 8A (138 mg, 0.57 mmol) and tert-butyl 4-chloro-3-cyano-5,8-dihydrothieno[2,3-b:5,4-c′]dipyridine-7(6H)-carboxylate (200 mg, 0.57 mmol) from Example 53A to yield 234 mg (74%).

後処理

  1. customto yield 234 mg (74%)

出典と根拠

ORDレコード
ord-08d53609cbe642179b61832c5b9f1a0c
出典データセット
uspto-grants-2013_09
特許番号
US08524722B2

関連ノート

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