Hydrochloric Acid → [2-Fluoro-4-(1-hydroxy-1-methyl-ethyl)-phenyl]-acetaldehyde

HRID 385705ノート

反応式

HRID 385705 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C:12]([OH:15])([CH3:14])[CH3:13])[CH:5]=[CH:6][C:7]=1[CH:8]=[CH:9][O:10]C.Cl>CC(C)=O.O.C(OCC)C>[F:1][C:2]1[CH:3]=[C:4]([C:12]([OH:15])([CH3:14])[CH3:13])[CH:5]=[CH:6][C:7]=1[CH2:8][CH:9]=[O:10]

参加物

6

反応物 2

HCID 313Hydrochloric AcidHCID 671174472-{3-Fluoro-4-[2-methoxyvinyl]phenyl}propan-2-ol

生成物 1

HCID 58216657[2-Fluoro-4-(1-hydroxy-1-methyl-ethyl)-phenyl]-acetaldehyde

試薬・触媒・溶媒 3

HCID 180Acetone溶媒HCID 962Water溶媒HCID 3283Diethyl Ether溶媒

実験手順

To a room temperature solution of 2-{3-fluoro-4-[2-methoxyvinyl]phenyl}propan-2-ol (100 mg, 0.48 mmol) in acetone (5 mL) was added dropwise 4 M aqueous hydrochloric acid (5 mL, 20 mmol). The reaction was stirred at room temperature for two hours. The mixture was then diluted with 25 mL of water and 50 mL of diethyl ether. The water phase was extracted with diethyl ether (2×) and the combined organic layers were washed with saturated aqueous sodium bicarbonate and brine, dried and concentrated in vacuo to afford the title compound.

後処理

  1. extractionThe water phase was extracted with diethyl ether (2×)
  2. washthe combined organic layers were washed with saturated aqueous sodium bicarbonate and brine
  3. customdried
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-7039acb10c7b48e4a9b5ebf19bbb03b0
出典データセット
uspto-grants-2013_02
特許番号
US08367706B2

反応ノート

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