Hydrochloric Acid → [2,6-Difluoro-4-(1-hydroxy-1-methyl-ethyl)-phenyl]-acetaldehyde

HRID 385709ノート

反応式

HRID 385709 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C:13]([OH:16])([CH3:15])[CH3:14])[CH:5]=[C:6]([F:12])[C:7]=1[CH:8]=[CH:9][O:10]C.Cl>CC(C)=O>[F:1][C:2]1[CH:3]=[C:4]([C:13]([OH:16])([CH3:14])[CH3:15])[CH:5]=[C:6]([F:12])[C:7]=1[CH2:8][CH:9]=[O:10]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 670288782-{3,5-Difluoro-4-[2-methoxyvinyl]phenyl}propan-2-ol

生成物 1

HCID 59525773[2,6-Difluoro-4-(1-hydroxy-1-methyl-ethyl)-phenyl]-acetaldehyde

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A solution of 2-{3,5-difluoro-4-[2-methoxyvinyl]phenyl}propan-2-ol (5.0 g, 22 mmol) in acetone (25 mL) was added dropwise to 4 M aqueous hydrochloric acid (25 mL, 100 mmol) with ice-water cooling, keeping the temperature below 10° C. Then the mixture was stirred at room temperature for six hours. The resulting mixture was extracted with ethyl acetate (2×) and the combined organic phases were washed with saturated aqueous sodium bicarbonate and brine. The organic layer was then dried and concentrated in vacuo to afford the title compound.

後処理

  1. customthe temperature below 10° C
  2. extractionThe resulting mixture was extracted with ethyl acetate (2×)
  3. washthe combined organic phases were washed with saturated aqueous sodium bicarbonate and brine
  4. customThe organic layer was then dried
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-61d0ccc73edd4c0d8a1fa039bb5e8d42
出典データセット
uspto-grants-2013_02
特許番号
US08367706B2

反応ノート

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