Dimethylformamide dimethyl acetal → HCID 178484334、化合物

HRID 385741ノート

反応式

HRID 385741 の反応式
[N+:1]([C:4]1[S:8][C:7]([C:9]([NH2:11])=[O:10])=[CH:6][CH:5]=1)([O-:3])=[O:2].CO[CH:14](OC)[N:15]([CH3:17])[CH3:16]>CN(C=O)C>[CH3:14][N:15](/[CH:17]=[N:11]/[C:9]([C:7]1[S:8][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=1)=[O:10])[CH3:16]

参加物

4

反応物 2

HCID 78373Dimethylformamide dimethyl acetalHCID 3147105-Nitrothiophene-2-carboxamide

生成物 1

HCID 178484334HCID 178484334、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
120 °C

実験手順

5-Nitrothiophene-2-carboxamide (5.80 g, 33.7 mmol) was combined with N,N-dimethylformamide dimethyl acetal (75 mL, 560 mmol) and stirred at 120° C. overnight (added 10 mL DMF to help dissolve the starting material). The red-brown solution was cooled to room temperature, at which point a solid precipitated from solution. The solid was isolated by filtration, washed with Et2O, and dried to provide the title compound as tan crystals.

後処理

  1. dissolutionto help dissolve the starting material)
  2. temperatureThe red-brown solution was cooled to room temperature, at which point a solid
  3. customprecipitated from solution
  4. customThe solid was isolated by filtration
  5. washwashed with Et2O
  6. customdried

出典と根拠

ORDレコード
ord-78ab10ec18db451f96a7d192dfc996a2
出典データセット
uspto-grants-2013_02
特許番号
US08367706B2

反応ノート

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