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Hydrazinecarboxaldehyde → 5-(4-Bromophenyl)-1H-1,2,4-triazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrazinecarboxaldehyde | HCID 12229 | — |
| 反応物 | Ethyl 4-bromobenzene-1-carboximidate | HCID 10466301 | — |
| 溶媒 | O-Xylene | HCID 7237 | — |
| 生成物 | 5-(4-Bromophenyl)-1H-1,2,4-triazole | HCID 46948734 | — |
反応手順
Into a 1000 mL 3-necked flask, was placed a solution of ethyl 4-bromobenzenecarboximidoate (54.0 g, 237 mmol) in xylene (500 mL) To the mixture was added NH2NHCHO (14.22 g, 237 mmol). The resulting solution was heated to reflux overnight. The reaction mixture was cooled in an ice bath and filtered. The solid was washed with 700 mL of petroleum ether and dried in an oven under reduced pressure to afford 3-(4-bromophenyl)-1H-1,2,4-triazole (crude) as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08367706B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-a6dfce0089d44b1f9ed693d88e2046e9 |
| 出典メモ | uspto-grants-2013_02 |