Hydrazinecarboxaldehyde → 5-(4-Bromophenyl)-1H-1,2,4-triazole

HRID 385751

反応式

HRID 385751 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[NH:12])OCC)=[CH:4][CH:3]=1.[NH2:13][NH:14][CH:15]=O>C1(C)C(C)=CC=CC=1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:12]=[CH:15][NH:14][N:13]=2)=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 12229HydrazinecarboxaldehydeHCID 10466301Ethyl 4-bromobenzene-1-carboximidate

生成物 1

HCID 469487345-(4-Bromophenyl)-1H-1,2,4-triazole

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

実験手順

Into a 1000 mL 3-necked flask, was placed a solution of ethyl 4-bromobenzenecarboximidoate (54.0 g, 237 mmol) in xylene (500 mL) To the mixture was added NH2NHCHO (14.22 g, 237 mmol). The resulting solution was heated to reflux overnight. The reaction mixture was cooled in an ice bath and filtered. The solid was washed with 700 mL of petroleum ether and dried in an oven under reduced pressure to afford 3-(4-bromophenyl)-1H-1,2,4-triazole (crude) as a white solid.

後処理

  1. customInto a 1000 mL 3-necked flask, was placed
  2. temperatureThe resulting solution was heated
  3. temperatureto reflux overnight
  4. temperatureThe reaction mixture was cooled in an ice bath
  5. filtrationfiltered
  6. washThe solid was washed with 700 mL of petroleum ether
  7. customdried in an oven under reduced pressure

出典と根拠

ORDレコード
ord-a6dfce0089d44b1f9ed693d88e2046e9
出典データセット
uspto-grants-2013_02
特許番号
US08367706B2

関連ノート

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