2-Amino-5-(2-fluorophenyl)thiophene-3-carboxamide → 5-(2-Fluorophenyl)-2-{[6-(1-hydroxy-1-methylethyl)pyridin-2-yl]amino}thiophene-3-carboxamide
反応式
Br[C:2]1[N:7]=[C:6]([C:8]([OH:11])([CH3:10])[CH3:9])[CH:5]=[CH:4][CH:3]=1.[NH2:12][C:13]1[S:14][C:15]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[F:27])=[CH:16][C:17]=1[C:18]([NH2:20])=[O:19]>>[F:27][C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=1[C:15]1[S:14][C:13]([NH:12][C:2]2[CH:3]=[CH:4][CH:5]=[C:6]([C:8]([OH:11])([CH3:10])[CH3:9])[N:7]=2)=[C:17]([C:18]([NH2:20])=[O:19])[CH:16]=1参加物
3
実験手順
The title compound was prepared according to the general procedure in Example 1 using 2-(6-bromopyridin-2-yl)propan-2-ol (65 mg, 0.301 mmol) and 2-amino-5-(2-fluorophenyl)thiophene-3-carboxamide (72.5 mg, 0.307 mmol) as the starting materials.
出典と根拠
- ORDレコード
- ord-ef09bd2c84804c07a85cd10cbd443ff0
- 出典データセット
- uspto-grants-2013_02
- 特許番号
- US08367706B2
反応ノート
読み込み中…