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(2E)-4-(Dimethylamino)-2-butenoic acid hydrochloride → 7-[(2E)-4-(Dimethylamino)but-2-enoyl]-N-[(1R)-1-phenylethyl]-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (2E)-4-(Dimethylamino)-2-butenoic acid hydrochloride | HCID 45358758 | — |
| 反応物 | N-[(1R)-1-Phenylethyl]-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-amine | HCID 49788713 | — |
| 生成物 | 7-[(2E)-4-(Dimethylamino)but-2-enoyl]-N-[(1R)-1-phenylethyl]-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-amine | HCID 49788490 | — |
反応手順
In analogy to Example 89, the title compound was prepared from N-[(1R)-1-phenylethyl]-5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-amine from Example 18A (100 mg, 0.32 mmol) and (2E)-4-(dimethylamino)but-2-enoic acid hydrochloride from Example 1A (75 mg, 0.45 mmol) to yield 23 mg (17%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08524722B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-0f20630317b44e9692729d04b26d6702 |
| 出典メモ | uspto-grants-2013_09 |