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2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-({[(1R,2R)-2-hydroxycyclopentyl]oxy}methyl)pyridin-2-yl]amino}thiophene-3-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide | HCID 59525619 | — |
| 反応物 | (1R,2R)-2-[(6-Bromopyridin-2-yl)methoxy]cyclopentanol | HCID 59526405 | — |
| 生成物 | 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-({[(1R,2R)-2-hydroxycyclopentyl]oxy}methyl)pyridin-2-yl]amino}thiophene-3-carboxamide | HCID 59525564 | — |
反応手順
The title compound was prepared as described in Example 1 with 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (0.14 g, 0.43 mmol) and (1R,2R)-2-[(6-bromopyridin-2-yl)methoxy]cyclopentanol (0.12 g, 0.43 mmol) as the starting materials.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08367706B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-e14b3d22f9a54d0787cca9a7c04661dc |
| 出典メモ | uspto-grants-2013_02 |