2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → HCID 59525961、化合物

HRID 385879

反応式

HRID 385879 の反応式
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]([N:10]2[CH2:14][CH2:13][C@@H:12]([O:15][CH3:16])[CH2:11]2)=[O:9])[N:3]=1.[NH2:17][C:18]1[S:19][C:20]([C:26]2[CH:31]=[CH:30][C:29]([C:32]([OH:35])([CH3:34])[CH3:33])=[CH:28][C:27]=2[F:36])=[CH:21][C:22]=1[C:23]([NH2:25])=[O:24]>>[F:36][C:27]1[CH:28]=[C:29]([C:32]([OH:35])([CH3:33])[CH3:34])[CH:30]=[CH:31][C:26]=1[C:20]1[S:19][C:18]([NH:17][C:2]2[CH:7]=[CH:6][CH:5]=[C:4]([C:8]([N:10]3[CH2:14][CH2:13][C@@H:12]([O:15][CH3:16])[CH2:11]3)=[O:9])[N:3]=2)=[C:22]([C:23]([NH2:25])=[O:24])[CH:21]=1

参加物

3

反応物 2

HCID 582166382-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 595256092-bromo-6-{[(3R)-3-methoxypyrrolidin-1-yl]carbonyl}pyridine

生成物 1

HCID 59525961HCID 59525961、化合物

実験手順

The title compound was prepared as described Example 1 using 2-bromo-6-{[(3R)-3-methoxypyrrolidin-1-yl]carbonyl}pyridine (53 mg, 0.19 mmol) and 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (55 mg, 0.19 mmol) as starting materials.

出典と根拠

ORDレコード
ord-1f5d23d003f549abac479cdaeea3a13c
出典データセット
uspto-grants-2013_02
特許番号
US08367706B2

関連ノート

読み込み中…