Hydrogen Peroxide → 2-(6-Bromopyridin-2-yl)-2-methylpropanamide
反応式
[Br:1][C:2]1[N:7]=[C:6]([C:8]([CH3:12])([CH3:11])[C:9]#[N:10])[CH:5]=[CH:4][CH:3]=1.OO.C(=O)([O-])[O-:16].[K+].[K+]>CS(C)=O>[Br:1][C:2]1[N:7]=[C:6]([C:8]([CH3:12])([CH3:11])[C:9]([NH2:10])=[O:16])[CH:5]=[CH:4][CH:3]=1参加物
5
反応条件
- 温度
- 70 °C
実験手順
To a solution of 2-(6-bromopyridin-2-yl)-2-methylpropanenitrile (Example 367, Step 1) (200 mg, 0.89 mmol) in dimethylsulfoxide (4 mL) was added hydrogen peroxide (0.42 mL, 4.8 mmol) and potassium carbonate (1.23 g, 8.89 mmol). The reaction was then stirred overnight at 70° C. The resulting slurry was cooled to ambient temperature, filtered and directly purified by reverse phase HPLC (10-100% acteonitrile/water+0.05% TFA modifier) to yield the title compound.
後処理
- temperatureThe resulting slurry was cooled to ambient temperature
- filtrationfiltered
- customdirectly purified by reverse phase HPLC (10-100% acteonitrile/water+0.05% TFA modifier)
出典と根拠
- ORDレコード
- ord-78b45d5989f648298460c2852aeefe9f
- 出典データセット
- uspto-grants-2013_02
- 特許番号
- US08367706B2
反応ノート
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