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1-(6-Bromopyridin-2-yl)pyrrolidin-3-ol → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(3-hydroxypyrrolidin-1-yl)pyridin-2-yl]amino}thiophene-3-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(6-Bromopyridin-2-yl)pyrrolidin-3-ol | HCID 21942298 | — |
| 反応物 | 2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide | HCID 59525619 | — |
| 生成物 | 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(3-hydroxypyrrolidin-1-yl)pyridin-2-yl]amino}thiophene-3-carboxamide | HCID 59526160 | — |
反応手順
The title compound was prepared according to the procedure described in Example 1 using 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (200 mg, 0.64 mmol) and 1-(6-bromopyridin-2-yl)pyrrolidin-3-ol (132 mg, 0.54 mmol) as the starting materials.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08367706B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-590bf84e50ee4317b0b87f7168954de3 |
| 出典メモ | uspto-grants-2013_02 |