HCID 45788475、化合物 → HCID 59525713、化合物

反応式

[NH2:1][C:2]1[S:3][C:4]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17]([OH:20])([CH3:19])[CH3:18])=[CH:12][C:11]=2[F:21])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Br[C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([C:29]2[CH:30]=[N:31][N:32]([CH3:34])[CH:33]=2)[N:24]=1>>[F:16][C:15]1[CH:14]=[C:13]([C:17]([OH:20])([CH3:18])[CH3:19])[CH:12]=[C:11]([F:21])[C:10]=1[C:4]1[S:3][C:2]([NH:1][C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([C:29]3[CH:30]=[N:31][N:32]([CH3:34])[CH:33]=3)[N:24]=2)=[C:6]([C:7]([NH2:9])=[O:8])[CH:5]=1

参加物

反応物 2

HCID 45788475HCID 45788475、化合物

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

生成物 1

HCID 59525713HCID 59525713、化合物

実験手順

The title compound was prepared as described in Example 1 using 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (150 mg, 0.48 mmol) and 2-bromo-6-(1-methyl-1H-pyrazol-4-yl)pyridine (114 mg, 0.48 mmol) as starting materials.

出典と根拠

ORDレコード: ord-af7bfc9181af4afab89af2fcc80e108d
出典データセット: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08367706B2

反応ノート

読み込み中…