Hydrazine → 6-Chloro-2-methylnicotinohydrazide

HRID 385965ノート

反応式

HRID 385965 の反応式
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[C:4]([CH3:11])[N:3]=1.[NH2:12][NH2:13]>C(O)C>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH:12][NH2:13])=[O:7])=[C:4]([CH3:11])[N:3]=1

参加物

4

反応物 2

HCID 9321HydrazineHCID 462238396-Chloro-2-methylpyridine-3-carboxylic acid

生成物 1

HCID 595262086-Chloro-2-methylnicotinohydrazide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

6-Chloro-2-methylnicotinic acid (Example 425, Step 1) (480 mg, 2.59 mmol) was taken up in ethanol (5.2 ml). Hydrazine (0.8 ml, 12.93 mmol) was added and the reaction was heated to 80° C. overnight. It was then concentrated under reduced pressure and purified via silica gel chromatography (0-3% methanol in ethyl acetate) to yield the title compound.

後処理

  1. concentrationIt was then concentrated under reduced pressure
  2. custompurified via silica gel chromatography (0-3% methanol in ethyl acetate)

出典と根拠

ORDレコード
ord-a1171008c2dd4f439d6475d347bd0f01
出典データセット
uspto-grants-2013_02
特許番号
US08367706B2

反応ノート

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