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2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-[(6-methyl-5-{[2-(3-oxomorpholin-4-yl)ethoxy]methyl}pyridin-2-yl)amino]thiophene-3-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide | HCID 59525619 | — |
| 反応物 | 4-{2-[(6-Chloro-2-methylpyridin-3-yl)methoxy]ethyl}morpholin-3-one | HCID 59525966 | — |
| 生成物 | 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-[(6-methyl-5-{[2-(3-oxomorpholin-4-yl)ethoxy]methyl}pyridin-2-yl)amino]thiophene-3-carboxamide | HCID 59525651 | — |
反応手順
The title compound was prepared as described in Example 1 using 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (150 mg, 0.48 mmol) and 4-{2-[(6-chloro-2-methylpyridin-3-yl)methoxy]ethyl}morpholin-3-one (137 mg, 0.48 mmol) as starting materials.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08367706B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-d6033eb9cede4d8fb763bb092014af0d |
| 出典メモ | uspto-grants-2013_02 |