Carbon tetrabromide → 2-Bromo-6-(1-bromo-2-fluoroethyl)pyridine
反応式
[Br:1][C:2]1[N:7]=[C:6]([CH:8](O)[CH2:9][F:10])[CH:5]=[CH:4][CH:3]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Br)(Br)(Br)[Br:32]>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]([CH:8]([Br:32])[CH2:9][F:10])[N:7]=1参加物
5
実験手順
1-(6-Bromopyridin-2-yl)-2-fluoroethanol (0.525 g, 2.39 mmol) and triphenylphosphine (1.252 g, 4.77 mmol) were taken up in DCM (25 mL). A solution of carbon tetrabromide (1.582 g, 4.77 mmol) in DCM (10 mL) was added and the resulting mixture stirred at room temperature overnight. The precipitate was removed by filtration and the filtrate concentrated in vacuo. Purification of the residue by silica gel column chromatography (0-10% EtOAc-hexanes) gave the title compound as a colorless oil.
後処理
- customThe precipitate was removed by filtration
- concentrationthe filtrate concentrated in vacuo
- customPurification of the residue by silica gel column chromatography (0-10% EtOAc-hexanes)
出典と根拠
- ORDレコード
- ord-3690968ecc6f47458254116afc17fff1
- 出典データセット
- uspto-grants-2013_02
- 特許番号
- US08367706B2
反応ノート
読み込み中…