関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Bromo-6-(bromomethyl)pyridine | HCID 12954796 | — |
| 反応物 | HCID 178418936 | HCID 178418936 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-bromo-6-(2H-1,2,3-triazol-2-ylmethyl)pyridine | HCID 59525913 | — |
| 生成物 | 2-bromo-6-(1H-1,2,3-triazol-1-ylmethyl)pyridine | HCID 59526296 | — |
反応手順
2-Bromo-6-(bromomethyl)pyridine (Example 190, Step 1) (1.50 g, 5.98 mmol), 1H-1,2,3-triazole (520 mL, 8.97 mmol), and K2CO3 (1.652 g, 11.96 mmol) were combined in DMF (5.0 mL) and stirred at 50° C. overnight. The mixture was diluted with water and extracted with EtOAc (2×). The combined organic layers were washed with brine, dried (MgSO4), filtered, and evaporated. Flash chromatography (0-100% EtOAc/hexanes) separated the two regioisomeric products to provide 2-bromo-6-(1H-1,2,3-triazol-1-ylmethyl)pyridine (lower Rf) and 2-bromo-6-(2H-1,2,3-triazol-2-ylmethyl)pyridine (higher Rf) as colorless solids.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08367706B2 |
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| 出典データセット | uspto-grants-2013_02 |
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| ORD ID | ord-505833c16d4d489597ec0678d217be8e |
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| 出典メモ | uspto-grants-2013_02 |
|---|
