2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({6-[1-(2-hydroxyethyl)-1H-1,2,3-triazol-4-yl]pyridin-2-yl}amino)thiophene-3-carboxamide
反応式
Br[C:2]1[N:7]=[C:6]([C:8]2[N:9]=[N:10][N:11]([CH2:13][CH2:14][OH:15])[CH:12]=2)[CH:5]=[CH:4][CH:3]=1.[NH2:16][C:17]1[S:18][C:19]([C:25]2[C:30]([F:31])=[CH:29][C:28]([C:32]([OH:35])([CH3:34])[CH3:33])=[CH:27][C:26]=2[F:36])=[CH:20][C:21]=1[C:22]([NH2:24])=[O:23]>>[F:36][C:26]1[CH:27]=[C:28]([C:32]([OH:35])([CH3:34])[CH3:33])[CH:29]=[C:30]([F:31])[C:25]=1[C:19]1[S:18][C:17]([NH:16][C:2]2[CH:3]=[CH:4][CH:5]=[C:6]([C:8]3[N:9]=[N:10][N:11]([CH2:13][CH2:14][OH:15])[CH:12]=3)[N:7]=2)=[C:21]([C:22]([NH2:24])=[O:23])[CH:20]=1参加物
3
反応物 2
生成物 1
実験手順
The title compound was synthesized from 2-[4-(6-bromopyridin-2-yl)-1H-1,2,3-triazol-1-yl]ethanol (108 mg, 0.40 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (125 mg, 0.40 mmol) according to the general procedure in Example 1.