n,n-Dimethylpiperazine-1-carboxamide → 4-[(2E)-4-{4-[(3-Chloro-5-hydroxyphenyl)amino]-5,8-dihydropyrido[4',3':4,5]thieno[2,3-d]-pyrimidin-7(6H)-yl}-4-oxobut-2-en-1-yl]-N,N-dimethylpiperazine-1-carboxamide

HRID 38607

反応式

HRID 38607 の反応式
Br[CH2:2]/[CH:3]=[CH:4]/[C:5]([OH:7])=O.Cl.[Cl:9][C:10]1[CH:11]=[C:12]([OH:30])[CH:13]=[C:14]([NH:16][C:17]2[C:18]3[C:25]4[CH2:26][CH2:27][NH:28][CH2:29][C:24]=4[S:23][C:19]=3[N:20]=[CH:21][N:22]=2)[CH:15]=1.[CH3:31][N:32]([CH3:41])[C:33]([N:35]1[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]1)=[O:34]>>[Cl:9][C:10]1[CH:15]=[C:14]([NH:16][C:17]2[C:18]3[C:25]4[CH2:26][CH2:27][N:28]([C:5](=[O:7])/[CH:4]=[CH:3]/[CH2:2][N:38]5[CH2:37][CH2:36][N:35]([C:33]([N:32]([CH3:41])[CH3:31])=[O:34])[CH2:40][CH2:39]5)[CH2:29][C:24]=4[S:23][C:19]=3[N:20]=[CH:21][N:22]=2)[CH:13]=[C:12]([OH:30])[CH:11]=1

参加物

4

反応物 3

HCID 712909n,n-Dimethylpiperazine-1-carboxamideHCID 64364114-Bromocrotonic acidHCID 668500883-Chloro-5-(5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol hydrochloride

生成物 1

HCID 581169724-[(2E)-4-{4-[(3-Chloro-5-hydroxyphenyl)amino]-5,8-dihydropyrido[4',3':4,5]thieno[2,3-d]-pyrimidin-7(6H)-yl}-4-oxobut-2-en-1-yl]-N,N-dimethylpiperazine-1-carboxamide

実験手順

In analogy to Example 130, the title compound was prepared from (2E)-4-bromobut-2-enoic acid (84 mg, 0.41 mmol), 3-chloro-5-(5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol hydrochloride from Example 65A (100 mg, 0.27 mmol) and N,N-dimethylpiperazine-1-carboxamide (68 mg, 0.43 mmol) to yield 59 mg (38%).

後処理

  1. customto yield 59 mg (38%)

出典と根拠

ORDレコード
ord-1ba13dacd352496a8ab6b199f4a36e8f
出典データセット
uspto-grants-2013_09
特許番号
US08524722B2

関連ノート

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