6-Bromopyridine-2-carbaldehyde → 6-bromopyridine-2-carbaldehyde O-(2-hydroxy-2-methylpropyl)oxime

HRID 386121ノート

反応式

HRID 386121 の反応式
[Br:1][C:2]1[N:7]=[C:6]([CH:8]=O)[CH:5]=[CH:4][CH:3]=1.Cl.[NH2:11][O:12][CH2:13][C:14]([CH3:17])([OH:16])[CH3:15]>C(O)C.C(OCC)(=O)C>[OH:16][C:14]([CH3:17])([CH3:15])[CH2:13][O:12][N:11]=[CH:8][C:6]1[CH:5]=[CH:4][CH:3]=[C:2]([Br:1])[N:7]=1

参加物

5

反応物 2

HCID 27570096-Bromopyridine-2-carbaldehydeHCID 231323651-(Aminooxy)-2-methylpropan-2-ol hydrochloride

生成物 1

HCID 866462866-bromopyridine-2-carbaldehyde O-(2-hydroxy-2-methylpropyl)oxime

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

A solution of 6-bromopyridine-2-carbaldehyde (334 mg, 1.80 mmol) and 1-(aminooxy)-2-methylpropan-2-ol hydrochloride salt (254.6 mg, 1.80 mmol) were stirred in ethanol (5 ml) for one hour at 10° C. The reaction mixture was cooled to room temperature and diluted with ethyl acetate. The organic layer was washed with water, dried over magnesium sulfate, filtered, and concentrated under reduced pressure. Column chromatography from 100% hexanes to 30% ethyl acetate afforded the title compound as E/Z mixture.

後処理

  1. washThe organic layer was washed with water
  2. dry with materialdried over magnesium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-a97deab2865842c3bf18d98b09f58e49
出典データセット
uspto-grants-2013_02
特許番号
US08367706B2

反応ノート

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