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HRID 386122作成日：2026年10月26日

2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(1-hydroxy-1-methylethyl)pyridazin-3-yl]amino}thiophene-3-carboxamide

https://huagongshe.com/reaction/386122

反応式

関与物質

役割名称HCID仕込み量
反応物2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 58216638—
反応物2-(6-Chloropyridazin-3-yl)propan-2-olHCID 59526161—
生成物5-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(1-hydroxy-1-methylethyl)pyridazin-3-yl]amino}thiophene-3-carboxamideHCID 59525859—

反応手順

The title compound was prepared by using the procedure listed in Example 1 with starting materials 2-(6-chloropyridazin-3-yl)propan-2-ol (Intermediate 45) (117 mg, 0.68 mmol) and 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (200 mg, 0.68 mmol).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08367706B2
出典データセットuspto-grants-2013_02
ORD IDord-9c87e8e43b5343138ba63c401fc048ec
出典メモuspto-grants-2013_02