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Iodoethane → 1-Trityl-4-ethoxymethylpyrazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Iodoethane | HCID 6340 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | (1-Trityl-1H-pyrazol-4-yl)methanol | HCID 10688521 | — |
| 反応物 | 1-Trityl-4-methoxymethylpyrazole | HCID 68530902 | — |
| 反応物 | 3,5-Dimethyl-4-methoxyethyl-1-tritylpyrazole | HCID 68531047 | — |
| 生成物 | 1-Trityl-4-ethoxymethylpyrazole | HCID 68528513 | 87% |
反応手順
This compound is a slightly yellow solid and has been obtained as described in 2b for 1-trityl-4-methoxymethylpyrazole, starting from 1-trityl-4-hydroxymethylpyrazole (1.250 g; 3.67 mmol), sodium hydride (221 mg; 5.51 mmol) and iodoethane (1.5 mL; 18.35 mmol), as described in example 2a for 3,5-dimethyl-4-methoxyethyl-1-tritylpyrazole. Yield: 87% (1.174 g, 3.19 mmol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08372379B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-6313e100383644858b4d27bb783987bc |
| 出典メモ | uspto-grants-2013_02 |