1-Acetylnaphthalene → 2-Bromo-1-(1-naphthalenyl)ethanone
反応式
[C:1]1([C:11](=[O:13])[CH3:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[Br:14]Br>O1CCOCC1>[Br:14][CH2:12][C:11]([C:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1)=[O:13]参加物
4
実験手順
To a solution of 1-(naphthalen-1-yl)ethanone (500 mg, 2.9 mmol) in dioxane (5 mL) was added to a solution of bromine (510 mg, 3.19 mmol) in dioxane (10 mL), at room temperature, over a period of 30 minutes. The reaction mixture was then stirred at room temperature for 20 minutes and concentrated. The resulting residue was diluted with ether and washed with saturated sodium bicarbonate, water, dried over sodium sulfate and concentrated. Purification by preparative thin layer chromatography (70% DCM/30% hexanes) afforded 2-bromo-1-(naphthalen-1-yl)ethanone (673 mg, 93%).
後処理
- concentrationconcentrated
- additionThe resulting residue was diluted with ether
- washwashed with saturated sodium bicarbonate, water
- dry with materialdried over sodium sulfate
- concentrationconcentrated
- customPurification by preparative thin layer chromatography (70% DCM/30% hexanes)
出典と根拠
- ORDレコード
- ord-28433479610f4dd89803e5dd0db30856
- 出典データセット
- uspto-grants-2013_02
- 特許番号
- US08372807B2
反応ノート
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