8-(2-Dimethylamino-4-nitro-phenyl)purin-6-one → 8-(4-Amino-2-dimethylamino-phenyl)purin-6-one

HRID 3864ノート

反応式

HRID 3864 の反応式
[CH3:1][N:2]([CH3:22])[C:3]1[CH:8]=[C:7]([N+:9]([O-])=O)[CH:6]=[CH:5][C:4]=1[C:12]1[N:20]=[C:19]2[C:14](=[N:15][CH:16]=[N:17][C:18]2=[O:21])[N:13]=1.[H][H]>CO.[Ni]>[NH2:9][C:7]1[CH:6]=[CH:5][C:4]([C:12]2[N:20]=[C:19]3[C:14](=[N:15][CH:16]=[N:17][C:18]3=[O:21])[N:13]=2)=[C:3]([N:2]([CH3:22])[CH3:1])[CH:8]=1

参加物

5

反応物 2

HCID 201532228-(2-Dimethylamino-4-nitro-phenyl)purin-6-oneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 201532408-(4-Amino-2-dimethylamino-phenyl)purin-6-one

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

An amount of 0.9 gm of 8-(2-dimethylamino-4-nitro-phenyl)purin-6-one is hydrogenated in 50 ml of methanol in the presence of 0.5 gm of Raney nickel at ambient temperature and under 5 bars of pressure with hydrogen for three hours until the calculated quantity has been taken up. After the catalyst has been subjected to suction filtration, the filtrate is evaporated to dryness in vacuo.

後処理

  1. filtrationAfter the catalyst has been subjected to suction filtration
  2. customthe filtrate is evaporated to dryness in vacuo

出典と根拠

ORDレコード
ord-7272044c980b48afb3322c501ec35ccc
出典データセット
uspto-grants-1988_02
特許番号
US04722929

反応ノート

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