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HRID 386529作成日：2026年10月27日
2-Bromopropionic acid, (S)- → (2R)-2-{4-[5-(Trifluoromethyl)pyridin-2-yl]piperazin-1-yl}propanoic acid
https://huagongshe.com/reaction/386529
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Bromopropionic acid, (S)- | HCID 642232 | — |
| 反応物 | 1-(5-Trifluoromethyl-pyridin-2-yl)-piperazine | HCID 667618 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (2R)-2-{4-[5-(Trifluoromethyl)pyridin-2-yl]piperazin-1-yl}propanoic acid | HCID 66628726 | — |
反応手順
A solution of 1-(5-trifluoromethyl-pyridin-2-yl)-piperazine (2.77 g, 11.99 mmoles) in DCM (42 mL) and TEA (4.2 mL) was treated with (2S)-2-bromo-propionic acid (1.19 mL, 13.2 mmoles) and stirred overnight at 35° C. The DCM was removed under reduced pressure to provide crude title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08372841B2 |
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| 出典データセット | uspto-grants-2013_02 |
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| ORD ID | ord-4fc5d9f994cd4b2c981883b6cff25c8d |
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| 出典メモ | uspto-grants-2013_02 |
|---|
