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Triethylamine → N-(6-acetylbenzo[d][1,3]-dioxol-5-yl)-3-(benzyloxy)-5-methoxybenzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 1-(6-Amino-1,3-benzodioxol-5-yl)ethan-1-one | HCID 120000 | — |
| 反応物 | 3-(Benzyloxy)-5-methoxybenzoyl chloride | HCID 12658783 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | N-(6-acetylbenzo[d][1,3]-dioxol-5-yl)-3-(benzyloxy)-5-methoxybenzamide | HCID 58052627 | — |
反応手順
Into solutions of 163 (2.77 g, 0.01 mmol) in 200 mL of dry tetrahydrofuran were added triethylamine (10 mL) and 2-amino-4,5-methylenedioxy acetophenone (148) (1.79 g, 0.01 mmol). The mixtures were stirred at room temperature for 24 h and then evaporated. The residue was purified by column chromatography (SiO2, CH2Cl2/EtOAc=3/1) to give 164.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08524740B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-c239a359c16f4968aa3d81de3e877c11 |
| 出典メモ | uspto-grants-2013_09 |