HCID 59129205、化合物 → 5-methyl-6-nitro-1H-indole

反応式

[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[NH:7][CH2:6][CH2:5]2>O1CCOCC1>[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[NH:7][CH:6]=[CH:5]2

参加物

反応条件

温度: 80 °C

実験手順

5-Methyl-6-nitroindoline (0.75 gr) was dissolved in 20 mL dioxane and treated with 1.5 g of dichloro dicyano quinone. The solution was heated at 80° C. for two hours, then cooled to room temperature and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by flash chromatography to give 0.5 g of 5-methyl-6-nitroindole (e/z (M+H) 177).

後処理

temperaturecooled to room temperature
filtrationfiltered
concentrationThe filtrate was concentrated under reduced pressure
customthe residue was purified by flash chromatography

出典と根拠

ORDレコード: ord-e43a2c6cdfb3456ba75f1f582c0d2e14
出典データセット: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08372865B2

反応ノート

読み込み中…

参加物

反応物 1

HCID 59129205HCID 59129205、化合物

生成物 1

HCID 212183045-methyl-6-nitro-1H-indole収率 67.4%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

反応条件

温度: 80 °C

実験手順

後処理

temperaturecooled to room temperature
filtrationfiltered
concentrationThe filtrate was concentrated under reduced pressure
customthe residue was purified by flash chromatography

出典と根拠

ORDレコード: ord-e43a2c6cdfb3456ba75f1f582c0d2e14
出典データセット: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08372865B2

反応ノート

読み込み中…