化工社化工社 化学情報印刷レポート · 研究参考用
Dimethyl Sulfate → 4-(4-Methoxy-3-ethoxyphenyl)-3-buten-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethyl Sulfate | HCID 6497 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 4-(3-Ethoxy-4-hydroxyphenyl)but-3-en-2-one | HCID 69247429 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 4-(4-Methoxy-3-ethoxyphenyl)-3-buten-2-one | HCID 53960274 | 65.3% |
反応手順
Anhydrous sodium carbonate (3.98 g) and dimethyl sulfate (3.78 g, 30 mmol) were added to a solution of 4-(4-hydroxy-3-ethoxyphenyl)-3-buten-2-one (6.2 g, 30 mmol) in acetone (40 ml). The reaction mixture was stirred under refluxing for 8 hr. The precipitated yellow solid was filtered, washed with acetone, and then recrystallized from anhydrous ethanol to give 4.3 g of a yellow crystal, mp 95-96° C., yield 65.3%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08524744B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-78ec42e1d23b4d7b91bc52b5997e61ff |
| 出典メモ | uspto-grants-2013_09 |