Chlorosuccinimide → HCID 46218813、化合物
反応式
[Cl:1]N1C(=O)CCC1=O.[O:9]1[CH2:14][CH2:13][CH:12]([C:15]2[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][C:16]=2[OH:22])[CH2:11][CH2:10]1>ClCCl>[Cl:1][C:19]1[CH:20]=[C:15]([CH:12]2[CH2:11][CH2:10][O:9][CH2:14][CH2:13]2)[C:16]([OH:22])=[CH:17][C:18]=1[OH:21]参加物
4
実験手順
2.4 g of N-chlorosuccinimide are added to a solution of 2 g of 4-(tetrahydropyran-4-yl)benzene-1,3-diol (Example 1) in 30 ml of dichloromethane at 0° C. The reaction mixture is stirred at ambient temperature for 16 hours. The reaction mixture is extracted with dichloromethane and then washed with water. The organic phases are combined and then dried over sodium sulphate. The residue is chromatographed on silica gel (75/25 heptane/ethyl acetate). 400 mg of 4-chloro-6-(tetrahydropyran-4-yl)benzene-1,3-diol are obtained. Yield=17%.
後処理
- extractionThe reaction mixture is extracted with dichloromethane
- washwashed with water
- dry with materialdried over sodium sulphate
- customThe residue is chromatographed on silica gel (75/25 heptane/ethyl acetate)
出典と根拠
- ORDレコード
- ord-927ece7fa95d4b21af35b319ba63e514
- 出典データセット
- uspto-grants-2013_02
- 特許番号
- US08372879B2
反応ノート
読み込み中…