化工社化工社 化学情報印刷レポート · 研究参考用
Diisopropylethylamine → 1-(3,4-dimethylphenyl)-4-(3-(1,5-diphenyl-1H-pyrazol-3-yl)propyl)piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 1-(3,4-Xylyl)piperazine | HCID 2723782 | — |
| 反応物 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 反応物 | 3-(1,5-diphenyl-1H-pyrazol-3-yl)propanal | HCID 42631135 | — |
| 生成物 | 1-(3,4-dimethylphenyl)-4-(3-(1,5-diphenyl-1H-pyrazol-3-yl)propyl)piperazine | HCID 25065048 | — |
反応手順
74 mg (83%) of target compound was obtained by using a method same as in Example 1 by using 3-(1,5-diphenyl-1H-pyrazol-3-yl)propanal (55 mg, 0.199 mmol), 1-(3,4-dimethylphenyl)piperazine (32 mg, 0.166 mmol), DIPEA (0.035 mL, 0.199 mmol) and NaBH(OAc)3 (148 mg, 0.697 mmol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08372844B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-8278d555e080401e9bac405463a3269a |
| 出典メモ | uspto-grants-2013_02 |